Cortisone therapy must be considered as useless in the treatment of colitis ulcerosa chiefly because it causes undesirable side effects such as Cushing's syndrome or osteoporosis. Generally speaking, in accordance with the present invention, a subject suffering from colitis ulcerosa is administered an effective dose of penicillamine, particularly D-penicillamine.

The present invention further provides for the treatment of colitis ulcerosa wherein a highly effective action is achieved with minimum toxicity and lack of undesired side effects. Other objects and advantages of the present invention will be apparent from further reading of the specification and of the appended claims. With the above and other objects in view, the present invention mainly comprises the treatment of colitis ulcerosa by administering to the patient suffering from the same an effective amount of penicillamine. Although the L-isomer and the DL-isomer of penicillamine are both active for the same purposes as the D-penicillamine, their toxicity is so much higher than D-penicillamine, that as a practical matter the D-penicillamine is used for the purposes of the present invention. The use of penicillamine in the treatment of provides considerable advantages in that the penicillamine in contrast to other immunosuppressive drugs acts extracellular, so that it is less toxic and the possibility of particular side effects is avoided. The dosage of the penicillamine of course depends upon the extent of the condition being treated. Thus, the higher the degree of cross linking and the more insoluble collagens, the higher the dosage of the penicillamine required to achieve the therapeutic effect. Likewise, the duration of administration is also dependent upon the degree of cross linking and amount of scar formation. In most cases a suitable dosage program would be the administration of 0.3 g of D-penicillamine for one week, then increasing the dosage by 0.3 g per day for an additional week until the full dosage of 1.8 g per day is arrived at. This dosage program is most desired in order to avoid any side effects.

After achieving the therapeutic effect, the dosage can be reduced to 0.6 g per day and then later completely eliminated. In particularly difficult conditions, it is possible to increase the daily dosage for a short time up to a daily dosage of 5 g of D-penicillamine.It is generally satisfactory to administer the penicillamine orally. In the case of highly advanced conditions it may be advisable to use a higher dosage, particularly at the beginning of the treatment, and in such case a dosage of 1 g of the D-penicillamine intravenously is advantageous. The penicillamine may be used for the purposes of the present invention in the form of its free base or in the form of an acid addition salt thereof, particularly of a mineral acid, such as hydrochloric acid.

In the preparation of products for oral administration or for administration by injection it is desirable to avoid the presence of oxygen which causes deterioration of the pharmaceutical action as a result of autoxidation with formation of penicillamine-disulfide. In order to avoid contact with the air, it is advisable to provide the oral form in air-tight, sealed hard gelatin capsules or in air-tight tablet form. For parenteral administration the penicillamine may be in the form of a solution, however in a special form which minimizes the decomposition of the penicillamine and also does not harm the patient upon injection through the skin. Since the mineral acid addition salt of penicillamine, such as D-penicillamine-hydrochloride are quite acid (pH of about 2), the solution of the acid addition salt in water for injection should have buffers added thereto in order to increase the pH of the solution. Among the suitable buffers for this purpose are tris (hydroxyamino) methane, borox-succinic acid buffer of Kolthoff, citrate buffer of Sorensen, citric acid-phosphate buffer of McIlvaine, glycol buffer of Sorensen, potassium biphthalate buffer of Clark and Lubs, standard acetate buffer of Michaelis and others.

For oral administration, the minimum daily dose is generally about 0.6 g with a maximum of about 2.4 g per day, the preferred oral administration being by means of tablets each containing 0.3 g, so that the daily administration of tablets is between 2 and 8 tablets per day. As indicated previously, however, for short periods of time, and in cases of severe conditions, the daily dose may be as high as 5 g. In the case of parenteral administration, which can be intraveneous or intramuscular, with intravenous being preferred because of greater certainty of pharmacological action, the unit dose is between about 0.5 g of D-penicillamine and 1.5 g. This dose is preferably administered as one injection per day. The preferred daily individual dose is about 1.0 g of D-penicillamine. Penicillamine may be used in accordance with the present invention not only in the treatment of human beings, but also in animals.

The oral dosage of penicillamine in the treatment of dogs and cats is generally between about 20 and 30 mg/kg of body weight, and preferably about 25 mg/kg. The parenteral dosage is between about 10 and 20 mg/kg and preferably about 15 mg/kg of body weight. In the case of horses and cattle, the oral daily dosage is generally between about 15 and 25 mg/kg and preferably about 20 mg/kg of body weight, the parenteral dosage being between about 5 and 15 mg/kg and preferably about 10 mg/kg of body weight. 
 
 

There are also herbal medicines which can very effectively treat colitis & ulcerative colitis. Boswellia is an Ayurvedic  (Indian traditional medicine) herb, used as a natural alternative to drugs. One study has found its effectiveness similar to sulfasalazine. (Source Wikipedia: http://en.wikipedia.org/wiki/Ulcerative_colitis ). 

We recommend taking a 4 months course of our Boswellia Serrata Extract.
 
 

Total of 4 bottles-  of Boswellia - 4 Months course - Taken 2 capusles twice a day.
 
 

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